Research Article

Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord

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Science  23 Oct 2020:
Vol. 370, Issue 6515, pp. 431-436
DOI: 10.1126/science.abb4608

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Spinal circuit development

Motor neuron circuits in the zebrafish spinal cord support both the rapid evasion response and the leisurely swimming response. Kishore et al. now follow the development of inhibitory interneurons as these circuits are assembled in the larva. Interneurons generated early in development drive different sorts of circuits and synapse onto different subcellular sections of the motor neurons than interneurons generated later in development. Thus, both rapid evasion and slower swimming are supported by the same cellular components assembled in different ways. The authors suggest that development follows an opportunistic rule in which interneurons synapse onto what is available to them at that moment in development.

Science, this issue p. 431

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